PhD course in Translational Specialistic Medicine 'G.B. Morgagni'

Clinical and Translational Neurosciences

Clinical Neurobiology and Neurogenetics: the genetic localization of different neurological diseases and the study of candidate genes. The study of pathogenetic mutations: genotype-phenotype correlations. Genetic expression studies using microarrays and real-time PCR analysis. Neuromuscular diseases: etio-pathogenetic mechanisms in the various forms of muscular dystrophy, of motor neuron diseases, mitochondrial and metabolic diseases, and peripheral neuropathies. Neuroimmunology: markers of immunologic damage in myasthenia gravis and peripheral neuropathies. Neurotoxic complications of chemotherapy in patients with cancer. Neurophysiopathology: characterization of the types of muscular fibers and of the factors of atrophy and hypertrophy. Intervention in the reparative processes of the central and peripheral nervous system of stem cells. Receptors of the central and peripheral nervous system. Otorhinolaryngology: Ototoxicity and otoprotection on sensory hair cells and neurons involved in auditory signal transduction. Mechanisms of cisplatin-induced ototoxicity and otoprotection. Regenerative medicine using nanoparticles to improve drug delivery to the organo of Corti and study of the potential toxic effects of these nanoparticles at high concentrations in vitro and in vivo, and their effects on cell metabolism. Cochlear implantation: development of surgical approaches and neurophysiological testing. Biological factors influencing tumor proliferation in cranial nerves to derive predictors of tumor growth in term of prognosis and to achieve high functional (facial nerve and hearing) preservation rates. The study of vestibulogy associated malfunctions and disorders.
 
Coordinator of the Curriculum:  Prof.ssa Elena Pegoraro